Stephen Jones

Histone Deacetylases

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. These HDAC family m... Read >

Monoclonal Antibody to Dnmt3a (Clone 64B814.1)

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic D... Read >

TLR8- cluster of differentiation 288

Toll-like receptor 8 (TLR8) often designated as CD288 (cluster of differentiation 288) is a member of evolutionarily conserved Toll-like receptor family which are critical parts of the evolutionarily conserved innate immune system. TLR8 has been identifie... Read >

TLR6- cluster of differentiation 286

Toll-like receptor 6 (TLR6) often designated as CD286 (cluster of differentiation 286), is a member of the Toll-like receptor family, a highly conserved series of ancient innate immune pattern recognition receptors. TLR6 was first described by Takeuchi et... Read >

TLR5- cluster of differentiation 285

Toll-like receptor 5 (TLR5), a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens. Like all other members of the TLR family, TLR5 is composed of an extrace... Read >

Stem Cell Marker (SCM)- The c-kit ligand

Hematopoiesis is governed by a number of cytokines that promote the survival, proliferation, and differentiation of hematopoietic stem cells and progenitor cells. Stem cell Marker (SCM; also known as kit ligand, mast cell growth factor, or steel factor) i... Read >

Toll-Like Receptor(TLR) : Unique Antibody from Imgenex

Toll-like receptor (TLR) family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs are evolutionarily conserved and their congeners have been found in insects, plants, and mammals. Drosophila Toll... Read >

Data Validation through Tissue Analysis

The existing body of literature using Western blot analysis has been primarily defined with data from tumor, immortal, and primary cells growing in vitro. Collectively, results obtained over decades have been integral to the dogma that up- and down-regula... Read >

Improved RNA interference kits launched by Imgenex

RNA interference (RNAi) is the process of mRNA degradation that is induced by double-stranded RNA in a sequence-specific manner. RNAi has been observed in all eukaryotes, from yeast to mammals. The RNAi pathway is thought to be an ancient mechanism for pr... Read >

Regulatory T Cells (Treg)

Early development and differentiation of nascent T cells that migrate from bone marrow to become mature, naïve T cells, which are capable of responding to antigen takes place inside the thymus. Around 1010 TCR (T cell receptor) variations are generated i... Read >

NF-kB Activation: Elucidating Upstream Events

The classical pathway for activation of NF-kB, a key transcriptional regulator of the immune system, is controlled by the IKK complex. Activated IKK phosphorylates IkB which is ubiquitinated and rapidly degraded, allowing NF-kB to translocate from the cy... Read >

GPCRs: Exploring New Paradigms

As one of the largest and most diverse protein families in nature, the G-protein coupled receptor (GPCR) superfamily play important roles in a variety of biological and pathological processes such as development and proliferation, neuromodulation, angio... Read >

Fundamental Immunology, Basic Immunology and Allergy Immunology

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. The immune system is the body's defense against infectious organisms and other invaders. Through a series of steps called the ... Read >

New FOXP3Δ2 (Exon 2 Deleted) Specific Antibody

FOXP3 is a master regulator of immune homeostasis expressed specifically in CD4+ CD25+ T regulatory cells controlling their growth, development and function. FOXP3 significance in the normal development of Tregs is better elucidated with the fact that mu... Read >

GPR83: A Novel Treg Expressed Cell Surface Marker

As research continues to unravel the molecular basis of regulatory T cells (Treg), FOXP3 has emerged as a key player in orchestrating development and function of natural Treg. Two recent publications identified GPR83 as specifically upregulated in fresh a... Read >